Wet Granulation
The wet granulation process is described below …
Granulation: from Latin for grained, A series of industrial unit processes used to force agglomeration and the formation of granules
Agglomeration: size enlargement during which fine powders are formed into larger, physically strong particle agglomerates, or granules, within which the original particles can be seen
Wet granulation involves the mixing of dry active ingredients and excipients using a fluid, which must be safe and volatile enough to be dried in a subsequent drying step. The binding liquid must also contain the binding agent as well as a solvent, such as water or alcohol.
Reasons for Granulating:
- To prevent segregation
- To improve the physical characteristics of the formulation for: flow, friability, density, dust control, aesthetics, etc.
Typical Wet Granulation Process:
